Calcitriol CAS No 32222-06-3
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|Min. Order:||100 mg|
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- Model NO.: C3078
- Color: White
- Name: Calcitriol CAS No 32222-06-3
- Molecular Weight: 416.64
- M.F: C27H44O3
- MDL Number: MFCD00867079
- Grade Standard: Medical Stand
- Trademark: Dieckmann
- Specification: 100mg, 1g, 5g, 25g, 100g/bottle
- Environmental Protection: Yes
- Appearance: Powder
- Synonym: 1, 25-Dihydroxycholecalciferol
- CAS No: 32222-06-3
- Purity: 99%Min
- Medicine Grade: USP
- Documents Available: Coa, MSDS, Nmr, HPLC
- Transport Package: 100mg, 1g, 5g, 25g, 100g/Bottle
- Origin: Shenzhen of China
|Synonmy||1α,25-Dihydroxyvitamin D3 1,25-Dihydroxycholecalciferol||M.F||C27H44O3|
|Storage||-20ºC,In N2,no light||Purity||98%min|
1. Calcitriol stimulates intestinal and renal Ca2+ absorption®ulates bone Ca2+ turnover.
2. With anti-tumor activity by inhibits in vivo and in vitro cell proliferation in a wide range of cells.
Calcitriol is a metabolite of the secosteroid vitamin D3. This hormone stimulates intestinal calcium transport at a much higher rate than vitamin D3 and hydroxy D3, and is considered to represent the biologically active form of vitamin D3. In addition to regulating the movement of calcium in the blood and bone, 1α,25-Dihydroxyvitamin D3 participates in developmental regulation and signaling. It stimulates an increase in protein kinase C levels with an effect on the regulation of c-myc transcription and activation of Raf kinase. 1α,25-Dihydroxyvitamin D3 is shown to increase the synthesis of prostacyclin with a correlated increase in cyclooxygenase activity, indicating a further role in vascular regulation. 1α,25-Dihydroxyvitamin D3 (Calcitriol) is an activator of PKC and VDR.
|Appearance||White or almost white crystals||Conform|
|Solubility||Practically insoluble in water, freely soluble in alcohol, soluble in fatty oils||Conform|
|Identification||Infrared spectrum corresponds to that of the standard preparation||Conform|
|The retention time of the major peak in the chromatogram corresponds to that in the chromatogram of standard preparation||Conform|
|Related Compounds||Trazoline adduct of pre-calcitriol:NMT 0.5%||ND|
|Trans-calcitriol: NMT 0.5%||0.17%|
|1β-Calcitriol: NMT 0.5%||ND|
|Any other individual impurity: NMT 0.1%||Conform|
|Total impurities: NMT 0.1%||0.28%|
|Loss on Drying||NMT 0.5%||<0.05%|
|Heavy Metals||NMT 20ppm||Conform|
|Residue on Ignition||NMT 0.1%||<0.05%|
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